繁华大都会美国纽约，邪恶领袖施莱德率领的大脚帮在城市内为非作歹，甚嚣尘上。安保公司老板埃里克·萨克斯（威廉·菲德内尔 William Fichtner 饰）推出最新安保系统，发誓维护城市的和平。第6频道女记者爱普尔·奥尼尔（梅根·福克斯 Megan Fox 饰）偶然拍到大脚帮被四名神秘侠客挫败的画面，在第二次遭遇非常事件时，她惊讶地发现四名侠客竟然是变异后的巴西龟：拉斐尔、列奥纳多、米可朗基罗、多纳泰罗。忍者神龟的名字勾起了爱普尔儿时的记忆，当年她的父亲与萨克斯正是研究生物变异实验的伙伴。她将这个消息告诉给萨克斯，可是在和忍者神龟及其老师斯普林特会面后，才发觉萨克斯与施莱德是这座城市内的罪恶之源……

城市需要英雄来拯救，黑暗降临纽约，大反派施莱德和他率领的异族用铁腕压制一切，从警察到政客都被其所控制。神龟们和无畏的女记者爱普莉尔以及聪明的摄像师菲诺通力合作，摧毁施莱德的恐怖计划，让这座城市重新恢复宁静。

When a kingpin threatens New York City, a group of mutated turtle warriors must emerge from the shadows to protect their home.

The Teenage Mutant Ninja Turtles are back in an all-new animated series on Nickelodeon! Surfacing topside for the first time on their fifteenth birthday, the titular turtles, Leonardo, Michelangelo, Raphael and Donatello, find that life out of the sewers isn't exactly what they thought it would be. Now the turtles must work together as a team to take on new enemies that arise to take over New York City.

After years of being sheltered from the human world, the Turtle brothers set out to win the hearts of New Yorkers and be accepted as normal teenagers through heroic acts. Their new friend April O'Neil helps them take on a mysterious crime syndicate, but they soon get in over their heads when an army of mutants is unleashed upon them.

The four turtles travel back in time to the days of the legendary and deadly samurai in ancient Japan, where they train to perfect the art of becoming one. The turtles also assist a small village in an uprising.

Batman, Batgirl, and Robin forge an alliance with the Teenage Mutant Ninja Turtles to fight against the Turtles' sworn enemy, The Shredder, who has apparently teamed up with Ra's Al Ghul and The League of Assassins.

Get lean, mean and green with the turtles team! Join Leo, Donnie, Ralph and Mikey as they take on the streets of NYC, where every turn yields a new enemy. Get ready for non-stop battles against Kraang-droids, mechanical Mousers, a mutant alligator, and even the evil Shredder himself. Episodes include: “Monkey Brains”, “Never say Xever”, “Enter Shredder”, “Panic in the sewers”, “Mousers Attack!”, “It came from the depths”, “New girl in town”

Get lean, mean and green with the turtles team! Join Leo, Donnie, Ralph and Mikey as they take on the streets of NYC, where every turn yields a new enemy. Get ready for non-stop battles against Kraang-droids, mechanical Mousers, a mutant alligator, and even the evil Shredder himself. Episodes include: “Monkey Brains”, “Never say Xever”, “Enter Shredder”, “Panic in the sewers”, “Mousers Attack!”, “It came from the depths”, “New girl in town”

Mayhem ensues as the Turtles face new dangerous mutants in a special double episode. The turtles try LARPing, Karai finally realises the truth, mutant villains steal retro-mutagen, and the city is invaded by a new mutant using living pizzas to attack!